Grasshopper Manufacture's Goichi Suda (Suda51) reckons that No More Heroes has done its dash on the Wii and it's time to move on.
He tells
Edge, "I think this is the last NMH that is going to be developed on Wii,” he added. “To expand NMH to new possibilities, we need a new platform. Wii is a great platform, but we’ve done everything we can with it now."
So, No More Heroes 2: Desperate Struggle could be the last we see on the Wii.