America's 10 Most Wanted enlists the military expertise of Criminal Interdiction and Fugitive Recovery's top agent in the hunt for US fugitives listed on the FBI website, including the notorious leader of the Al 'Queda terrorist network Osama Bin Laden and the ousted leader of Iraq Saddam Hussein. Commentary is provided by Dan Rathner, star news anchor for the US television network CBS over licensed news footage from CNN. In game music is provided by members of So Solid Crew who also make guest appearances in the game.